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CASTLE Study Announcement

By January 6, 2017April 3rd, 2018Research News

We are pleased to announce our new study exploring Changing Agendas on Sleep, Treatment and Learning in Childhood Epilepsy (CASTLE). The CASTLE study will be recruiting children with Rolandic epilepsy and their parents to research how their learning, sleep, behaviour, self-esteem and mood are impacted by epilepsy.

The treatment of epilepsy with drugs to reduce seizures has been the traditional goal of medical treatment. However, simply reducing seizures doesn’t always make a difference in the way children and parents feel. The drugs used to treat epilepsy may slow down a patient’s thinking and learning. Given that children with Rolandic epilepsy often ‘grow out’ of their seizures in teenage years, parents and clinicians are concerned that this may have a negative effect on their learning ability.

The CASTLE study will work with children, parents, doctors and nurses to choose the best ways to improve health and quality of life for children with epilepsy. Participants in this study will be randomly allocated to receive a combination of either no drug/carbamazepine/levetiracetam with a standard advice/sleep behaviour package, as well as completing questionnaires about general health and well-being. A subset of children will also have their memory tested.

The overall aim of the CASTLE study is to improve the treatment outlook and future for children affected by Rolandic epilepsy by involving both children and parents. We will receive £2.3 million in funding for this study and it will run from 2017-2023.

Read more about CASTLE →

CASTLE team; L:R Dr Chris Morris, Dr Lucy Bray, Deborah Roberts, Prof Paul Gringras, Dr Catrin Tudur-Smith, Prof Deb Pal, Janet Currier, Dr Frances Gibbon, Prof Bernie Carter, Dr Colin Dunkley (not pictured: Prof Dyfrig Hughes & Dr Luci Wiggs)